Protein Electrophoresis,serum

What is Serum protein electrophoresis Test?

A serum protein electrophoresis (SPEP) test analyzes the different proteins in your blood serum to diagnose and monitor health conditions like multiple myeloma, liver disease, kidney disease, and chronic infections. 

The serum protein electrophoresis (SPEP) test separates blood proteins into fractions (albumin, alpha-1, alpha-2, beta, gamma) to detect abnormal patterns such as a monoclonal “M‑protein” seen in plasma cell disorders.

Why consider Serum protein electrophoresis Test?

• Detect and monitor monoclonal gammopathies such as multiple myeloma, MGUS, Waldenström macroglobulinemia, and AL amyloidosis.
• Investigate abnormal total protein/albumin results, hypercalcemia, anemia, renal impairment, bone pain, recurrent infections, or unexplained elevated ESR.
• It helps evaluate unexplained high total protein, low albumin with high total protein, and symptoms suggestive of monoclonal gammopathies

Who should get this Serum protein electrophoresis Test?

• Individuals with clinical or laboratory features suggestive of plasma cell disorders (anemia, bone pain/lesions, hypercalcemia, renal dysfunction, proteinuria) or an unexplained high globulin gap.
• Patients needing evaluation of chronic inflammation, liver disease patterns, nephrotic syndrome, or immunodeficiencies where characteristic electrophoretic patterns aid assessment.

More Information about Serum protein electrophoresis Test

Blood protein (serum proteins) refers mainly to albumin and globulins that circulate in blood and perform transport, immune, and regulatory functions; abnormal levels or patterns can signal liver, kidney, inflammatory, or plasma cell disorders. The common clinical assessment is serum protein electrophoresis, which separates proteins into albumin, alpha-1, alpha-2, beta, and gamma regions to look for monoclonal spikes and other diagnostic patterns. 

OTHER NAMES: Serum Protein Electrophoresis, SPE test, SPEP test, Protein Electrophoresis, Blood Serum Protein Electrophoresis