Ena Profile (Extractable Nuclear Antigen Antibodies Panel)

What is the purpose of the abs to extractable nuclear antigen (SS-B) serum test?

This test detects antibodies against SS-B (La), a component of extractable nuclear antigens, which are associated with autoimmune diseases such as Sjögren's syndrome and systemic lupus erythematosus (SLE).


When is the SS-B serum test recommended?

The test is recommended when patients present with symptoms suggestive of Sjögren's syndrome or SLE, including dry mouth, dry eyes, and joint pain.


How is the SS-B serum test conducted?

A blood sample is collected, and an enzyme-linked immunosorbent assay (ELISA) or immunoblot technique is used to detect anti-SS-B antibodies.


What do positive and negative SS-B results indicate?

A positive result suggests the presence of autoimmune disease, most commonly Sjögren's syndrome or SLE. A negative result reduces the likelihood of these conditions but does not rule them out.