ACHR-Acetyl Choline Receptor Antibodies
Detects antibodies against the acetylcholine receptor, which are typically elevated in autoimmune diseases like myasthenia gravis. It aids in diagnosis and monitoring.
Overview of ACHR-Acetyl Choline Receptor Antibodies in Kasaragod
What is ACHR, Acetyl choline receptor antibody test?
A blood test that detects autoantibodies against acetylcholine receptors at the neuromuscular junction; these antibodies interfere with nerve-to-muscle signaling and are strongly associated with myasthenia gravis (MG).
Why consider ACHR, Acetyl choline receptor antibody test?
To support the diagnosis of MG in patients with compatible symptoms and to distinguish MG from other causes of fatigable weakness.
To establish a serologic baseline and, in some cases, track antibody levels over time alongside clinical response.
To evaluate for autoimmune risk when a thymoma is present, or when MG is suspected but clinical tests are inconclusive.
Who should get this ACHR, Acetyl choline receptor antibody test in Kasaragod?
Individuals with suggestive MG features: fluctuating muscle weakness that worsens with activity and improves with rest, ptosis, diplopia, dysphagia, dysarthria, neck flexor weakness, or exertional fatigue.
Patients with generalized or ocular MG suspicion, or with imaging evidence of thymic pathology (thymic hyperplasia/thymoma).
Seronegative patients for whom alternative antibodies (e.g., MuSK, LRP4) and electrophysiologic testing are being considered as part of a comprehensive workup.
More Information about ACHR, Acetyl choline receptor antibody test in Kasaragod?
Autoantibodies against acetylcholine receptors (AChRs) at the neuromuscular junction are immune proteins that mistakenly target the nicotinic AChRs on the muscle endplate, disrupting nerve-to-muscle signaling and causing fatigable weakness typical of myasthenia gravis. These antibodies can:
Bind and directly block ACh from activating the receptor, reducing ion channel opening and endplate depolarization.
Cross-link receptors, accelerating their internalization and degradation (antigenic modulation), which lowers receptor density.
Activate complement on the postsynaptic membrane, damaging the junctional folds and further impairing neuromuscular transmission.
OTHER NAMES: AChR Antibodies; Acetylcholine Receptor Antibody, Binding/Blocking/Modulating , Myasthenia Gravis Antibodies, Anti-AChR (Serum), acetylcholine receptor antibody, achr antibody, anti-achr test, myasthenia gravis test, mg antibody, neuromuscular junction antibody, achr test
Test included
- Achr- Acetyl Choline Receptor Antibodies
Doctor information
Test code
5559
CPT and Loinc codes
Department
- Eia - Auto Immune
Turn around time
Same Day
Test run frequency
Monday,Wednesday,Friday TIME - 11:00
Performing locations
2 labs across India
Specimen vol. and vacutainer information
| Specimen | Vacutainer | Volume |
|---|---|---|
| Serum | Yellow Vacutainer | 1 ml |
Specimen stability information
Serum
Test price
₹4600
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