Her 2/ Neu

What is HER 2/ NEU Test?

The HER2/neu test (also called ERBB2 test) is a diagnostic test used to measure the presence and amount of human epidermal growth factor receptor 2 (HER2) protein or gene amplification in breast cancer or other types of cancer tissue. HER2 is a protein that promotes the growth of cancer cells. In about 15–20% of breast cancers, the cancer cells make too much HER2 due to a gene mutation.

Thes results can be:

• HER2-negative: Little or no HER2 protein/gene expression. These patients won't benefit from HER2-targeted therapies.
• HER2-positive: High HER2 protein/gene expression. Candidates for HER2-targeted therapies.
• HER2-low: A newer category where low expression (IHC 1+ or 2+ with negative FISH) may be eligible targeted therpies

Why consider HER 2/ NEU Test?

The HER2/neu test is important because it helps:

• Determine cancer aggressiveness: HER2-positive cancers tend to grow and spread faster.
• Guide treatment decisions: HER2-positive cancers may respond to targeted therapies like trastuzumab (Herceptin), and others.
• Predict prognosis: HER2-positive cancers, if untreated, may have a worse prognosis—but targeted therapy has dramatically improved outcomes.

Who should get this HER 2/ NEU Test?

• Patients newly diagnosed with breast cancer (especially invasive breast cancer)
• Patients with metastatic (spread) breast cancer — Testing helps in determining the best treatment options.
• Gastric (stomach) cancers or gastroesophageal junction cancers, where HER2-targeted therapies may also be considered.
• Monitoring HER2 status in recurrent cancer, as HER2 expression can change over time.

More Information HER 2/ NEU Test

OTHER NAMES: HER2NEU, ERBB2, HER2 BY IHC, Herceptin

HER2 testing is a crucial part of personalized cancer treatment. The results help ensure that patients receive the most effective, targeted therapy for their specific cancer type.