DSA (Donor Specific IgG Antibodies to Class I & II)
The DSA test detects antibodies in the recipient’s blood that are directed against the donor’s organ after transplantation. It is critical for evaluating transplant rejection and managing post-transplant care. The test helps identify patients at risk for graft rejection.
Overview of DSA (Donor Specific IgG Antibodies to Class I & II) in Kottayam
What is DSA, Donor Specific IgG Antibodies to Class I & II test?
What is DSA, Donor Specific IgG Antibodies to Class I & II test is a blood test that detects IgG antibodies in a transplant recipient directed specifically against the donor’s HLA Class I (A, B, C) and Class II (DR, DQ, DP) antigens, which are a major cause of antibody‑mediated graft injury and rejection.
Why consider DSA, Donor Specific IgG Antibodies to Class I & II test in Kottayam?
Presence of DSA is strongly associated with antibody‑mediated rejection (AMR), graft dysfunction, and inferior graft survival across solid organ transplants, making it critical for risk assessment and monitoring.
Complement‑binding or certain IgG subclasses (notably IgG1/IgG3) indicate higher pathogenic potential, helping refine risk stratification and management decisions.
Who should get this DSA, Donor Specific IgG Antibodies to Class I & II test in Kottayam?
Transplant candidates during pre‑transplant workup to detect preformed DSA and guide organ acceptance, desensitization, or allocation strategies.
Post‑transplant recipients for routine surveillance or when there is graft dysfunction, to detect de novo DSA and guide timely interventions.
More Information about DSA, Donor Specific IgG Antibodies to Class I & II test in Kottayam
Donor-specific IgG antibodies are anti-HLA antibodies produced by a transplant recipient that specifically recognize the donor’s HLA Class I (A, B, C) and/or Class II (DR, DQ, DP) antigens, and they are a key biomarker for antibody-mediated rejection and graft injury.
Preformed DSA present before transplant can provoke hyperacute or early acute rejection and influence organ acceptance decisions, particularly if they cause a positive T-cell crossmatch.
Other Names: HLA DSA (Donor‑Specific Antibody) Class I & II; Donor‑specific HLA antibody; DSA monitoring; HLA antibody specificity monitoring
Test included
- Dsa Class I - Mean Fluoroscence Intensity (mfi)
- Dsa Class I Result
- Dsa Class Ii - Mean Fluoroscence Intensity (mfi)
- Dsa Class Ii Result
- Dsa Final Result
Doctor information
Test code
4810
CPT and Loinc codes
Department
- Hla Serology
Turn around time
2 Working Days
Performing locations
3 labs across India
Specimen vol. and vacutainer information
| Specimen | Vacutainer | Volume |
|---|---|---|
| Acd Whole Blood | Yellow Vacutainer | 2 ML |
| Serum | Yellow Vacutainer | 2 ML |
Specimen stability information
Acd Whole Blood, Serum
Collection instructions
Age,Gender,Clinical history required
Test price
₹11550
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₹11550