T Cell Lymphoma FISH Panel, Bone Marrow/Blood

What is T Cell Lymphoma FISH Panel test?

T Cell Lymphoma FISH Panel is a molecular cytogenetic test that uses FISH to detect chromosomal abnormalities and gene rearrangements associated with T-cell lymphomas. T Cell Lymphoma FISH panel analyzes bone marrow or peripheral blood samples to identify genetic alterations that help confirm the diagnosis of T-cell lymphomas, determine the specific subtype of T-cell lymphoma and guide treatment and prognostic evaluation. T-cell lymphomas are a heterogeneous group of rare non-Hodgkin lymphomas that arise from mature T lymphocytes.

Why consider T Cell Lymphoma FISH Panel test?

T Cell Lymphoma FISH Panel test can be considered for

• To confirm or classify T-cell lymphoma at the molecular level.

• To detect chromosomal rearrangements linked to aggressive disease or poor prognosis.

• To help guide targeted therapy or clinical management.

• To monitor disease progression or relapse during or after treatment.

• To differentiate T-cell lymphoma from other hematologic malignancies with similar presentation.

Who should get tested for T Cell Lymphoma FISH Panel test in Thrissur?

T Cell Lymphoma FISH Panel test is generally recommended for:

• Patients with suspected or confirmed T-cell lymphoma.

• Individuals showing abnormal T-cell populations in blood or bone marrow.

• Cases where histopathology or immunophenotyping is inconclusive.

• Patients undergoing risk stratification or therapy monitoring for T-cell malignancies.

They are generally more aggressive than B-cell lymphomas and can affect lymph nodes, blood, skin, and extranodal organs.

Common Subtypes

1. Peripheral T-Cell Lymphoma (PTCL) – general category for mature T-cell lymphomas

2. Anaplastic Large Cell Lymphoma (ALCL) – may express ALK protein

3. Angioimmunoblastic T-Cell Lymphoma (AITL) – often presents with immune dysfunction

4. Cutaneous T-Cell Lymphoma (CTCL) – primarily affects the skin (e.g., mycosis fungoides)