ALK (EML4-ALK) by FISH
This test detects rearrangements in the ALK gene using FISH technology, helping diagnose certain cancers, including non-small cell lung cancer.
Overview of ALK (EML4-ALK) by FISH in Aluva
What is ALK (EML4-ALK) by FISH test?
The ALK (EML4-ALK) by FISH test is a molecular diagnostic test used to detect a specific gene rearrangement in cancer cells — particularly in non-small cell lung cancer (NSCLC).
Why consider ALK (EML4-ALK) FISH test?
The ALK (EML4-ALK) FISH test is a crucial molecular diagnostic tool in non-small cell lung cancer (NSCLC). It detects a specific genetic alteration — the ALK gene rearrangement — which helps identify patients who may benefit from targeted therapy with ALK inhibitors.
ALK gene rearrangements (especially EML4-ALK fusion) are oncogenic drivers in about 3–7% of NSCLC cases (mostly adenocarcinoma). A positive ALK FISH result means the patient is eligible for targeted treatment with ALK inhibitors.
ALK-positive NSCLC patients respond very well to ALK inhibitors, with Higher response rates, Longer progression-free survival, Better quality of life and Fewer side effects than chemotherapy
Who should get tested for ALK (EML4-ALK) by FISH test in Aluva?
This test should be performed on patients with non-small cell lung cancer (NSCLC) who are being evaluated for targeted treatments. It assists oncologists in determining whether ALK inhibitor therapies are appropriate.
More Information about ALK (EML4-ALK) by FISH test in Aluva
ALK (EML4-ALK) refers to a gene fusion in which portions of the EML4 gene fuse with the ALK gene, creating a constitutively active tyrosine kinase driver found in a subset of non-small cell lung cancers (NSCLC), typically lung adenocarcinoma. This fusion promotes tumor growth via activation of downstream signaling pathways (RAS/ERK, PI3K/AKT/mTOR, STAT3) and is targetable with multiple generations of ALK tyrosine kinase inhibitors (TKIs) that have significantly improved outcomes in ALK-positive NSCLC
OTHER NAMES: ALK break-apart FISH (tissue), EML4-ALK FISH (tissue), ALK rearrangement by FISH (FFPE), ALK (2p23) gene rearrangement FISH (tissue), ALK fusion tissue (FISH), alk fish test, eml4-alk rearrangement, alk gene fusion fish, lung cancer alk test, crizotinib eligibility test, alk positive lung cancer fish
Test included
- Request Letter
- Specimen
- Block Identification Number
- Number Of Observers
- Total Number Of Cells Analysed
- Interpretation
Doctor information
Test code
6028F
CPT and Loinc codes
Department
- Cytogenetics
Turn around time
7 Working Days
Test run frequency
Every Day TIME - 07:00
Performing locations
1 labs across India
Specimen vol. and vacutainer information
| Specimen | Vacutainer | Volume |
|---|---|---|
| Paraffin Block | Others | 1 NOS |
Specimen stability information
Paraffin Block
Test price
₹13650
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₹13650