Endomysial Iga Antibody,serum

About Endomysial IgA Antibodies (IFA) test

It is a blood test that detects IgA antibodies directed against endomysium, a connective tissue protein in the small intestine. It is primarily used to help diagnose celiac disease, an autoimmune disorder triggered by gluten. A positive result indicates an immune response to gluten, suggesting that the body is attacking its own intestinal tissue. This test is highly specific for celiac disease and is often used alongside other serological tests and clinical evaluation.

Why consider Endomysial IgA Antibodies (IFA) test?

This test is considered when there is a suspicion of celiac disease, particularly in individuals with symptoms like chronic diarrhea, abdominal pain, bloating, or nutrient deficiencies. It is also used to confirm a diagnosis in patients who test positive on other celiac blood tests, due to its high specificity. Additionally, the test can help monitor adherence to a gluten-free diet, as antibody levels typically decrease when gluten is removed from the diet.

Who should get Endomysial IgA Antibodies (IFA) test done?

• Exhibit symptoms of celiac disease, such as chronic diarrhea, abdominal pain, bloating, or fatigue.
• Have unexplained nutrient deficiencies, like low iron, calcium, or vitamin D.
• Have a family history of celiac disease or other autoimmune disorders.
• Show positive results in preliminary celiac blood tests and need confirmation.
• Need monitoring of gluten-free diet adherence after a celiac disease diagnosis.
• Present with growth delays or poor weight gain, particularly in children.

More information about Endomysial IgA Antibodies (IFA) test

The Endomysial IgA antibody test can also be valuable in cases where patients have atypical or silent celiac disease, meaning they show minimal or non-classical symptoms. It is sometimes used in screening at-risk populations, such as individuals with type 1 diabetes, autoimmune thyroid disease, or Down syndrome, since these groups have a higher prevalence of celiac disease.

Other Names: Anti-Endomysial Antibody Test, EMA Antibody Test, Endomysial IgA Serology