Anti-Centromere B Antibody

The Anti-Centromere B Antibody test detects antibodies directed against the centromere B protein, a component of the chromosome involved in cell division. These antibodies are commonly associated with certain autoimmune connective tissue disorders, particularly limited cutaneous systemic sclerosis (CREST syndrome). The test helps support the diagnosis of autoimmune conditions when interpreted alongside symptoms, medical history, and other laboratory findings.

Who Should Get This Test Done?

This test may be recommended for:

●      Individuals with symptoms suggestive of systemic sclerosis, such as skin tightening or thickening.

●      Individuals experiencing Raynaud’s phenomenon (fingers or toes changing color in response to cold or stress).

●      Individuals with unexplained connective tissue disease symptoms.

●      Individuals undergoing evaluation for autoimmune disorders based on clinical findings.

●      Individuals advised by a rheumatologist to undergo autoimmune antibody testing.

Why Consider This Test?

This test can be considered because it helps identify antibodies associated with specific autoimmune connective tissue diseases. It supports the diagnosis of limited systemic sclerosis and complements other autoimmune investigations. The results can help clinicians differentiate between autoimmune conditions, guide further evaluation, and contribute to developing an appropriate management plan.

●      Helps detect Anti-Centromere B antibodies.

●      Supports the evaluation of systemic sclerosis and related disorders.

●      Assists in differentiating autoimmune connective tissue diseases.

●      Complements other autoimmune antibody tests.

●      Provides valuable information for diagnosis and clinical management.

More Information

Autoimmune diseases occur when the immune system mistakenly targets the body’s own tissues. Anti-Centromere B antibodies are considered important markers in the assessment of certain connective tissue disorders. While their presence can provide significant diagnostic clues, the results should always be interpreted along with clinical symptoms, physical examination, and additional laboratory tests to arrive at an accurate diagnosis.

Other Names

●      Anti-CENP-B Antibody

●      Centromere B Antibody Test

●      Anti-Centromere Antibody (ACA)

●      Anti-Centromere Protein B Antibody

●      CENP-B Antibody Test