Histone Antibody by ELISA

The Histone Antibody by ELISA, Serum test detects antibodies against histone proteins in the blood. Histones are proteins found within the cell nucleus that help organize DNA. The presence of anti-histone antibodies is commonly associated with drug-induced lupus erythematosus (DILE) and may also be seen in certain autoimmune disorders, including systemic lupus erythematosus (SLE). Performed using the Enzyme-Linked Immunosorbent Assay (ELISA) method, this test supports the evaluation of autoimmune conditions and is interpreted alongside clinical findings and other autoimmune antibody tests.

Who should get this test done?

This test may be recommended for individuals who:

●     Have symptoms suggestive of drug-induced lupus, such as joint pain, muscle aches, fever, or skin rash.

●     Are being evaluated for systemic lupus erythematosus (SLE) or other autoimmune diseases.

●     Develop lupus-like symptoms after starting certain medications.

●     Require further investigation following positive antinuclear antibody (ANA) test results.

●     Are advised by their healthcare provider to undergo autoimmune antibody testing.

Why consider this test?

Autoimmune disorders often share similar symptoms, making it difficult to identify the exact cause based on symptoms alone. The Histone Antibody by ELISA test helps detect antibodies that are strongly associated with drug-induced lupus and may also be present in some individuals with systemic lupus erythematosus. When interpreted alongside ANA, anti-dsDNA, and other autoimmune markers, this test provides valuable information that supports diagnosis, helps differentiate between autoimmune conditions, and guides further clinical evaluation.

More information

This test uses the ELISA (Enzyme-Linked Immunosorbent Assay) technique to detect anti-histone antibodies in a serum sample. It is frequently included as part of a broader autoimmune antibody profile when lupus or related autoimmune disorders are suspected. Since anti-histone antibodies can be detected in different clinical settings, the results should always be evaluated together with the individual’s symptoms, medication history, physical examination, and other laboratory investigations for an accurate clinical assessment.

Other names

●     Anti-Histone Antibody Test

●     Histone Antibody ELISA

●     Anti-Histone IgG Antibody Test

●     Histone Autoantibody Test

●     Anti-Histone Antibodies, Serum