Lymphoma T(11;18)(API2Malti1) Translocation, BMPB
Overview of Lymphoma T(11;18)(API2Malti1) Translocation, BMPB in Pathanamthitta
What is Lymphoma t(11;18)(API2/MALT1) translocation test?
The Lymphoma t(11;18)(API2/MALT1) translocation test is a molecular cytogenetic test performed on bone marrow samples to detect a specific chromosomal translocation between chromosomes 11 and 18 — denoted as t(11;18)(q21;q21).This rearrangement leads to the fusion of the API2 (also known as BIRC3) gene on chromosome 11 with the MALT1 gene on chromosome 18, forming the API2-MALT1 fusion gene. t(11;18) is a hallmark genetic abnormality associated primarily with MALT lymphoma (mucosa-associated lymphoid tissue lymphoma) and occasionally seen in other low-grade B-cell lymphomas.
Lymphoma t(11;18)(API2/MALT1) translocation test is usually performed using Fluorescence In Situ Hybridization (FISH) method to confirm the presence of this translocation in bone marrow or tissue samples.
Why consider Lymphoma t(11;18)(API2/MALT1) translocation test in Pathanamthitta?
Lymphoma t(11;18)(API2/MALT1) translocation test can be considered for -
To confirm the diagnosis of MALT lymphoma, particularly in cases involving bone marrow or disseminated disease.
To differentiate MALT lymphoma from other types of B-cell lymphomas with similar morphology.
To help determine prognosis — patients with this translocation often show resistance to antibiotic therapy (H. pylori eradication) and may require systemic treatment.
To guide treatment planning and risk stratification.
To monitor disease involvement in bone marrow.
Who should get tested for Lymphoma t(11;18)(API2/MALT1) translocation test in Pathanamthitta?
Lymphoma t(11;18)(API2/MALT1) translocation test is generally recommended for:
Patients with suspected or confirmed MALT lymphoma involving the stomach, lungs, salivary glands, or other extranodal sites.
Individuals with lymphoma showing plasmacytic differentiation or low-grade B-cell features.
Cases where lymphoma has spread to bone marrow and confirmation of molecular subtype is required.
Patients not responding to H. pylori eradication therapy, suggesting possible t(11;18) positivity.
It is typically slow-growing and often arises in organs with chronic inflammation or infection.
Test included
- Specimen
- Clinical Indications
- Total Number Of Cells Analysed
- T(11;18)(api2/malt1)(q22;q21)
- Normal
- Interpretation
Doctor information
Test code
10344
CPT and Loinc codes
Department
- Cytogenetics
Turn around time
8 Working Days
Performing locations
1 labs across India
Specimen vol. and vacutainer information
| Specimen | Vacutainer | Volume |
|---|---|---|
| Others (fx) | Others | 2 ML |
Specimen stability information
Others (Fx)
Test price
₹5000
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